Category: Longevity & Healthspan

  • Sitting and Longevity

    Sitting and Longevity

    Bernadino Ramazzini became interested in occupational diseases while still a medical student in Parma. He carefully observed the diseases experienced by different workers. He noted that although some were caused by occupational exposure to chemical or physical agents many occupational illnesses were due to prolonged postures, sudden movements or lack of motion. He observed that sedentary tailors were more likely to succumb to disease than flighty messengers. 

    Ramazzini made his shrewd observations in the early Enlightenment period. Now, a sedentary lifestyle has become the norm, especially in the workplace. A recent groundbreaking study, following in Ramazzini’s footsteps, has shed light on the health risks associated with prolonged occupational sitting. This research was conducted over two decades in Taiwan. It explores the silent but substantial impact of sitting for extended periods at work. The study also examines how modest increments in physical activity can counteract the detrimental effects of prolonged sitting.

    The Silent Threat of the Modern Workplace

    In recent years, the mantra “sitting is the new smoking” has echoed through the both corridors of public health and the echochambers of social media. In keeping with this, public health offcials and social media influencers urge us to reevaluate our sedentary habits via our mobile deives. The 2020 World Health Organization guidelines took a definitive stance (no pun) against prolonged sedentary behaviour. The guidelines highlighted its adverse health consequences. Yet, the specific dangers of occupational sitting, especially when combies with low levels of physical activity, remained relatively underexplored until now.

    The Sitting Study Cohort

    The study analysed the health outcomes of 481,688 participants. It revealed a stark contrast between the health of those who sit extensively at work and their more active counterparts. Individuals entrenched in sedentary occupations faced a 16% increase in all-cause mortality risk. In addition, they had a staggering 34% rise in cardiovascular disease mortality when compared to those whose jobs involve more standing or movement.

    However, there’s a potential silver lining. Alternating between sitting and standing at work, or incorporating just 15 to 30 minutes of additional leisure-time physical activity (LTPA) daily, can significantly mitigate against these risks. This finding introduces a new narrative. The idea that small, consistent changes in our daily routines can combat the health risks posed by a sedentary job.

    Get Up, Stand Up. Stand Up for Your…. Health

    The conversation around occupational health is slowly evolving. Standing desks and walking meetings are becoming more commonplace. This study does provide some validation for these trends which have often, reasonably, been thought of as faddish. It also highlights the necessity for a broader cultural shift in our workplaces and working practices. To some extent, it’s a call to action for employers and employees to embrace more dynamic work environments where movement is integrated into the fabric of our workdays.

    The Role of Personal Activity Intelligence (PAI)

    One of the most compelling aspects of the study is the introduction of the PAI metric. This is a personalised measure of physical activity. PAI considers the intensity and duration of exercise. Every time your heart rate increases you earn PAI points. The higher your heart rate goes up, the faster you accumulate PAI points. According to the study, achieving a PAI score greater than 100 was a robust strategy for counteracting the health risks associated with prolonged sitting. Indeed, Norwegian University of Science and Technology research suggests that people who achieve a PAI score of over 100 every week live an average of 8 years longer than those who don’t. PAI, therefore, offers a more tailored approach to health that goes beyond bland and generic recommendations. How do you achieve a PAI of over 100? Well, slightly annoyingly, there’s an app involved. However, it doesn’t take much to get a score of over 100. 2 hours of exercise at 80% of your maximum heart rate per week will get a PAI score of over 100. The beauty of PAI is that is adjusts to your fitness levels. The fitter you are, the harder, or longer you have to workto achieve your PAI. 

    Moving More, Sitting Less

    The implications of this research are clear. In combating the hazards of that come as the collateral damage of our sedentary modern life, every step counts. Whether it’s taking a brief walking break, choosing a stand-up desk, or dedicating a proportion of our free time to physical activity, these actions can collectively mitigate some the health risks posed by prolonged sitting.

    In essence, this study serves as a reminder that our health is in our hands (and feet). We have choice, agency, in how we move our bodies at work. It challenges us to rethink our daily routines, to find balance in movement, and to prioritise movement in the workplace and beyond. Ramazzini exhorted people in sedentary professions to take physical exercise…. and so to counteract the harm done by many days of sedentary life.” Today, as we continue to tackle the demands of modern work and living, be mindful that movement is not merely a part of life, it’s essential to living well.

    British Association of Sports and Exercise Medicine  ·  European Atherosclerosis Society  · 
    Independent Doctors Federation

    As seen in The Independent, The Daily Mail and Tatler

    For educational purposes. This article is written by a practising GP and is intended to inform, not replace a consultation with your own doctor. It does not constitute medical advice. A note on clinical guidelines: Coyne Medical is an independent private clinic. Our approach is guided by the best available evidence, tailored to each individual. This may go beyond standard NHS or NICE guidance, which is designed for population-level care and weighted by resource constraints.

  • Antibiotics and IBS: Complex Relationship

    Antibiotics and IBS: Complex Relationship

    Patients often get frustrated by doctors worrying about prescribing antibiotics. One of many reasons why doctors think twice before prescribing antibiotics is that the connection between antibiotic use and Irritable Bowel Syndrome (IBS) has emerged as a topic of growing interest. A large-scale case–control study involving 29,111 IBS patients and 135,172 controls offers new insights into this association.

    The Study: A Deeper Dive into Antibiotics and IBS

    Led by Staller et al. (2023), this study marks a significant step in understanding the potential link between antibiotic exposure and the later development of IBS. The researchers meticulously analysed data, focusing on antibiotic use more than a year before an IBS diagnosis.

    Key Findings: A Dose-Response Relationship

    • Increased IBS Risk with Antibiotic Use: The study found a significant association between any history of antibiotic exposure and a later diagnosis of IBS.
    • The More Antibiotics, the Higher the Risk: Notably, there was a dose–response relationship. Individuals with three or more historical antibiotic prescriptions faced a 2.36 to 3.36 times higher risk of being diagnosed with IBS.

    Tetracyclines: A Notable Culprit

    While all antibiotic classes were linked to IBS development, tetracyclines showed the highest association, hinting at a class-specific impact on gut health.

    Other Factors in the IBS Puzzle

    • GI Infection History: Interestingly, a personal history of GI infection up to a year prior to IBS diagnosis didn’t significantly change the odds of developing IBS.
    • The Role of Acute GI Infection: Acute GI infection could be the initial trigger, with antibiotic exposure providing a second hit that disrupts the microbiome and potentially leads to IBS.

    A Closer Look at the IBS Subtypes

    The high proportion of IBS with diarrhoea (57.7%) in this study does raise some questions about potential biases in the methodology, such as the selection of cases undergoing colonoscopy and biopsy.

    Psychological Factors and Healthcare Seeking Behaviour

    The absence of data on psychiatric illnesses and antidepressant medication use in this population is a gap, given the known association of mental health conditions with IBS. Additionally, the higher number of outpatient visits in the IBS group suggests that healthcare-seeking behaviour might influence the likelihood of receiving antibiotics.

    Broader Implications and Future Directions

    The increasing global misuse of antibiotics, coupled with the complexity of the gut microbiome influenced by diet, medications, and genetics, underscores the need for further research. Key questions remain: What specific changes in the microbiome lead to IBS? And can interventions like prebiotics, probiotics, or dietary changes offer protection?

    My Perspective

    One takeaway is clear: limiting unnecessary antibiotic prescriptions should be a top public health priority. Understanding and addressing the nuances of antibiotic use and its impact on gut health is crucial to improving gastrointestinal well-being.

    To a healthier gut and a wiser approach to antibiotics.

    Please help someone else by sharing this blog. 

    British Association of Sports and Exercise Medicine  ·  European Atherosclerosis Society  · 
    Independent Doctors Federation

    As seen in The Independent, The Daily Mail and Tatler

    For educational purposes. This article is written by a practising GP and is intended to inform, not replace a consultation with your own doctor. It does not constitute medical advice. A note on clinical guidelines: Coyne Medical is an independent private clinic. Our approach is guided by the best available evidence, tailored to each individual. This may go beyond standard NHS or NICE guidance, which is designed for population-level care and weighted by resource constraints.

  • Lipid-Lowering Therapy in Older Adults: A New Danish Study Sheds Light

    Lipid-Lowering Therapy in Older Adults: A New Danish Study Sheds Light

    There’s been a longstanding debate about the effectiveness and necessity of lipid-lowering therapies, especially statins, in older adults. A recent Danish cohort study involving 65,190 individuals aged 50 and above has provided some illuminating insights into this topic. The rates of use of statin therapy has been shown to decline in people above age 75. This applies even to people who are known to have cardiovascular disease. The decline in statin usage is even more sharp in those who do not have cardiovascular disease.  

    The Conventional Wisdom and the Emerging Data

    Traditionally, the focus of lipid-lowering therapy, particularly aiming to reduce low-density lipoprotein cholesterol (LDL-C), has been on younger populations. But does this mean our approach should differ as we age? This study suggests perhaps not.

    What the Study Reveals

    The Danish research team embarked on an observational study using national healthcare and administrative registries to understand the impact of initiating lipid-lowering treatments in older adults. Their findings:

    * Substantial Risk Reductions: For each 1mmol/L reduction in LDL-C, there was a 23% decreased risk of major vascular events, regardless of whether individuals were older or younger than 70.

    * Uniform Benefits Across Ages: These benefits were consistent in both the older (≥70 years) and younger (<70 years) groups, indicating that age does not diminish the effectiveness of these therapies.

    * Supportive Observational Data: Complementing this data are findings from Giral and colleagues, who observed lower rates of cardiovascular events in those who continued statin treatment past the age of 75, compared to those who stopped. It included people who had taken statins regularly but hadn’t had heart problems before. The study found that stopping statins increased the risk of hospital admission for heart issues by 33%.

    Broader Implications and Future Directions

    This study aligns with data from the Cholesterol Treatment Trialists Collaboration and other primary prevention trials. The Cholesterol Treatment Trialists Collaboration has been running since 1994. It conducts meta-analyses of cholesterol intervention trials. The Collaborations aims to assess whether interventions on lipid-lowering work in different types of people. A meta-analysis allows a more reliable assessment of the effect of an intervention than a single trial alone. Previously, they have demonstrated that statin therapy does not increase the risk of cancer or of other non-cardiac causes of death. The key takeaway is that lowering LDL-C levels is crucial for reducing cardiovascular risk, regardless of age.

    Two prospective randomised trials are also on the horizon, promising to provide more clarity on this topic for older adults. These include the STAREE study, focusing on patients over 70, and the SITE/SAGA study, examining statin cessation in individuals 75 years or older. While we now have some clarity for over 50s, there is still debate as to whether statins are useful and cost-effective for over 75s. These two studies should provide some clarity.

    My Perspective

    The message here is clear: preventing cardiovascular events is a universal goal, transcending age barriers. These new findings reinforce the importance of managing cholesterol levels even in older adults. It’s not about the number of candles on a birthday cake; it’s about the numbers that count for heart health. 

    For our younger patients, it’s important not to delay statin treatment. A study in the journal  Circulation analysed data to uncover when younger adults should start statins to prevent heart disease over 30 years. It found that starting cholesterol-lowering treatments in your 40s, especially if your LDL is high, could significantly reduce the risk of heart disease later on. This study suggests it might be more important to decide when to start treatment rather than if you should start at all.

    Make sure you have your discussed your risk of cardiovascular disease and discussed a plan to lower your risk with your GP.

    Please help another person improve their heart health by sharing this blog.

    British Association of Sports and Exercise Medicine  ·  European Atherosclerosis Society  · 
    Independent Doctors Federation

    As seen in The Independent, The Daily Mail and Tatler

    For educational purposes. This article is written by a practising GP and is intended to inform, not replace a consultation with your own doctor. It does not constitute medical advice. A note on clinical guidelines: Coyne Medical is an independent private clinic. Our approach is guided by the best available evidence, tailored to each individual. This may go beyond standard NHS or NICE guidance, which is designed for population-level care and weighted by resource constraints.

  • What is the best way to reverse diabetes?

    What is the best way to reverse diabetes?

    In the landscape of metabolic health, prediabetes exists as a silent prelude to Type 2 diabetes. A recent study offers significant insights into prediabetes remission.

    Understanding the Precursor

    Prediabetes is akin to standing on a railway platform, watching your train slowly approach, whilst snacking on a muffin in Starbucks on Platform 13. You have to catch the train, but to do so you need to ditch the muffin and get out of the coffee shop. The importance of catching this train before it departs cannot be overstated. It’s a critical juncture where blood sugar levels, though not high enough for a diabetes diagnosis, are certainly not in the clear. 

    Insights from the PLIS and DPP Studies

    The Prediabetes Lifestyle Intervention Study (PLIS) in Germany, in tandem with data from the Diabetes Prevention Program (DPP) in the USA, sheds light on reversing prediabetes. The focus was on individuals who achieved a notable weight loss, examining their metabolic health trajectory.

    Decoding the Study: Key Takeaways

    • Insulin Sensitivity and Weight Loss: An encouraging insight was the improvement in insulin sensitivity among those who lost weight. This factor is pivotal in maintaining healthy blood sugar levels.
    • The Role of Visceral Fat: The study underscored the reduction of visceral adipose tissue – a key player in metabolic health. This type of fat, cloaking the abdominal organs, is a silent contributor to metabolic diseases. By the way, MRI is a fantastic way to assess your levels of visceral fat.  
    • The Age Factor: Younger participants had a better response to lifestyle changes, underscoring the import of early intervention.

    Interpreting the Data: What It Means for You

    • Exercise as a Pillar of Health: I hate to always bang the same drum but regular physical activity emerged as a critical component of the lifestyle intervention. It’s a non-negotiable tool for enhancing insulin sensitivity.
    • Dietary Discipline: A balanced diet is about more than calories; it’s about fcreating a metabolic environment conducive to optimal health.
    • Proactive Approach: The study reinforces the principle that early intervention in prediabetes can significantly deter the progression to Type 2 diabetes.

    This study isn’t merely a warning sign; it’s a beacon of empowerment. Tackling prediabetes head-on with lifestyle adjustments can pivot your trajectory away from Type 2 diabetes.

    If you would like to prevent or improve diabetes, make sure you book an appointment with us. We can also arrange for you to have body composition by MRI and assess you visceral fat and muscle mass providing invaluable insights into your metabolism. 

    British Association of Sports and Exercise Medicine  ·  European Atherosclerosis Society  · 
    Independent Doctors Federation

    As seen in The Independent, The Daily Mail and Tatler

    For educational purposes. This article is written by a practising GP and is intended to inform, not replace a consultation with your own doctor. It does not constitute medical advice. A note on clinical guidelines: Coyne Medical is an independent private clinic. Our approach is guided by the best available evidence, tailored to each individual. This may go beyond standard NHS or NICE guidance, which is designed for population-level care and weighted by resource constraints.

  • What is the least amount of exercise you can do?

    What is the least amount of exercise you can do?

    A Step in the Right Direction

    In our journey towards better heart health, the common advice has often been to aim for 10,000 steps a day. But what if I told you that recent research suggests a more achievable daily goal can still offer significant health benefits?

    A comprehensive meta-analysis, studying data from 111,309 individuals across 12 studies, sought to unravel the true impact of our daily steps on cardiovascular health and overall mortality. The question at hand was simple, yet profound: what is the least number of steps one needs to take daily for cardiovascular benefits?

    Less May Be More

    The study revealed some eye-opening insights:

    • Modest Steps, Major Impact: As few as 2,517 to 2,735 steps per day marked a significant decrease in all-cause mortality and cardiovascular events. This is just a slight increase from the baseline of 2,000 steps.
    • Incremental Benefits: The relationship between steps and health benefits was dose-responsive. At approximately 8,763 steps, there’s a dramatic 60% reduction in mortality, while about 7,126 steps can cut down cardiovascular events by half.
    • Diminishing Returns Beyond a Point: Interestingly, beyond these optimal step counts, the incremental health benefits start to plateau.

    Cadence and Wearable Insights

    • Pace Matters: The study also highlighted that a higher step cadence (steps per minute) amplifies the health benefits.
    • Accuracy in Tracking: Interestingly, hip-worn sensors were more closely associated with health benefits compared to wrist-worn devices, likely due to more precise step counting.

    The Timing Question: What’s The Next Step?

    One intriguing aspect not addressed in the study is whether the timing of these steps (spread throughout the day vs. in one go) affects their health benefits. In an era where sedentary lifestyles are prevalent, understanding the impact of step distribution could be immensely valuable.

    Walking Towards Healthier Hearts

    So, what’s the takeaway for us? The once daunting 10,000-step goal seems less critical now. Starting with as little as 2,700 steps daily can offer substantial heart health benefits. And, if you can gradually increase your step count, the rewards for your heart health and longevity only get better.

    British Association of Sports and Exercise Medicine  ·  European Atherosclerosis Society  · 
    Independent Doctors Federation

    As seen in The Independent, The Daily Mail and Tatler

    For educational purposes. This article is written by a practising GP and is intended to inform, not replace a consultation with your own doctor. It does not constitute medical advice. A note on clinical guidelines: Coyne Medical is an independent private clinic. Our approach is guided by the best available evidence, tailored to each individual. This may go beyond standard NHS or NICE guidance, which is designed for population-level care and weighted by resource constraints.

  • Knee Osteoarthritis Treatment: The Role of Hyaluronic Acid Injections and Ultrasound Guidance

    Knee Osteoarthritis Treatment: The Role of Hyaluronic Acid Injections and Ultrasound Guidance

    Knee osteoarthritis (OA) is a degenerative joint disease that affects millions. The search for effective treatments has been ongoing, with intra-articular hyaluronic acid (IAHA) injections, such as Ostenil Plus and Durolane, emerging as promising options. However, there’s a discrepancy between the medical evidence backing IAHA and the varied recommendations from international guidelines. So, how effective really is this treatment, and does the method of injection play a role in its success?

    The Promising Potential of IAHA Injections for Knee OA

    Recent studies have focused on analysing the benefits and safety of IAHA injections. A comprehensive literature review, including randomized controlled trials and meta-analyses, highlighted the following:

    • Symptomatic Relief: IAHA, including Ostenil Plus, offers moderate relief to those with knee OA without significant safety concerns.
    • Impressive Benefit/Risk Ratio: When looking at improvements in knee OA outcomes, IAHA might have one of the best benefit-to-risk ratios among pharmacologic options. Notably, patients experience an overall increase in quality-adjusted life years and significant delays in needing total knee replacement.

    In light of these findings, it’s worth considering IAHA injections as a viable treatment option. However, the real game-changer might be in tailoring treatments by the stage of disease and specific patient characteristics. The future of IAHA treatment may involve identifying OA patient subgroups that show a more pronounced response to the treatment. Combining IAHA with other treatments might also offer optimised care for knee OA patients.

    Optimising Treatment with Ultrasound Guidance

    Viscosupplementation involves injecting hyaluronic acid into the knee. It has faced criticism due to inconsistent pain relief benefits. One major concern has been the accuracy of needle placement, especially in obese patients. Enter ultrasound (US) guidance.

    A study analysed community-dwelling patients receiving HA knee injections, comparing outcomes between those getting injections with traditional landmark guidance and those with US guidance. The results were compelling:

    • Similar Patient Cohorts: Both the US-guided and landmark-guided patient groups had similar demographics and arthritis severity.
    • Surgery-Free Outcomes: A significant number of patients in the landmark-guided group (45.8%) required knee arthroplasty (surgery), compared to only 33.2% in the US-guided group. The difference was even more pronounced among obese patients, with 51.8% in the landmark-guided group requiring surgery compared to 34.8% in the US-guided group.

    These findings suggest a clear conclusion: To optimise the benefits of viscosupplementation, ensuring accurate intra-articular needle placement via US guidance is crucial. When done right, patients receiving US-guided HA injections are less likely to require subsequent knee surgeries.

    In Conclusion

    Knee osteoarthritis is a challenging condition, but modern treatments like IAHA injections offer hope. When combined with advanced techniques like ultrasound guidance, these treatments can provide significant relief and improve the quality of life for many patients.

  • Everything you need to know about Ozempic & Navigating Weight Loss Injections

    Everything you need to know about Ozempic & Navigating Weight Loss Injections

    Debunking Misconceptions and Embracing Comprehensive Solutions

    The topic of weight loss injections has gained significant attention, particularly concerning medications like semaglutide, liraglutide (Saxenda, Wegovy), and Ozempic. In this article, Dr Hugh explains everything you need to know about Ozempic and navigating weight loss injections.

    However, before delving into the specifics of these medications, it is essential to address the broader issue of obesity and the misconceptions surrounding its treatment. Many individuals who are offered these medications to manage obesity and its associated health risks often hesitate due to perceived stigma and misconceptions about the nature of their condition.

    Redefining Obesity: A Chronic Disease

    Society’s historical tendency to stigmatise individuals who are overweight has resulted in many viewing obesity as a personal failure. This perception is not only unjust but also hinders effective treatment. It is vital to understand that obesity is indeed a chronic disease and has been classified as a chronic disease since the 1990s. Its impact on health and mortality has been recognised for over 2500 years, dating back to the time of Hippocrates.

    Understanding Obesity Pathogenesis

    Obesity is not merely a matter of willpower or self-control. Its pathogenesis involves two interconnected processes. The first is a sustained positive energy balance, resulting from small, incremental imbalances between energy intake and expenditure over time. Once an individual reaches a higher-than-normal weight, the second process emerges: the resetting of the body’s weight “set point” at an elevated value.

    This phenomenon can be understood through the lens of evolutionary physiology. Our biological predisposition to store body fat for survival was advantageous in times of scarcity but poses challenges in the modern era of abundance and easy access to calorie-dense foods. Consequently, a significant portion of the population is biologically inclined toward excessive weight gain. This intrinsic physiological mechanism explains why weight loss achieved through diet and lifestyle changes often leads to eventual weight regain, posing a considerable obstacle to effective obesity treatment.

    Debunking Stigma: Obesity as a Disease

    The stigma associated with obesity not only affects individuals emotionally but also hampers their access to appropriate treatments, including medications. It’s crucial to recognise that obesity is on par with other chronic diseases, such as type 2 diabetes. Just as one wouldn’t hesitate to manage diabetes with medication, obesity also requires a multifaceted approach to treatment.

    Comprehensive Solutions: Weight loss medications

    Weight loss medications, like semaglutide, liraglutide, and others, offer valuable tools in the management of obesity. However, it’s essential to view these medications as part of a broader strategy. Behaviour modification, dietary adjustments, increased physical activity, and in some cases, surgical interventions, all play integral roles in a comprehensive treatment plan. These components work synergistically to promote sustainable weight loss and improve overall health outcomes.

    Shifting the perspective on obesity

    Shifting the perspective on obesity from personal failure to a chronic disease is a crucial step in achieving effective treatment. By understanding the physiological mechanisms driving obesity, we can debunk misconceptions and encourage individuals to consider a comprehensive approach that encompasses medications, lifestyle changes, and supportive interventions. Of course, not everyone needs medications. Just because a medications offered to you, doesn’t mean you have to take it. Ideally, we would manage disease solely through lifestyle interventions. However, embracing a holistic strategy empowers individuals to fully take charge of their health.

    Please reach out to the team if you have any questions about the contents of this article.

    British Association of Sports and Exercise Medicine  ·  European Atherosclerosis Society  · 
    Independent Doctors Federation

    As seen in The Independent, The Daily Mail and Tatler

    For educational purposes. This article is written by a practising GP and is intended to inform, not replace a consultation with your own doctor. It does not constitute medical advice. A note on clinical guidelines: Coyne Medical is an independent private clinic. Our approach is guided by the best available evidence, tailored to each individual. This may go beyond standard NHS or NICE guidance, which is designed for population-level care and weighted by resource constraints.

  • Mineral Sunscreen: the Natural Shield Against Harmful Rays

    Mineral Sunscreen: the Natural Shield Against Harmful Rays

    Sunscreen is an essential item if you’re lucky to be getting a sunny break in. In fact we would recommend wearing a daily sunscreen with at least SPF (sun protection factor) 15 in London, you never quite know what the weather will be like and UV (ultraviolet) radiation is present all year. 

    Protection against both UVA and UVB radiation will protect your skin from ageing as well as damage which can lead to skin cancers. 

    Do you need a mineral sunscreen?

    A ‘mineral’ sunscreen sits on top of the skin and physically reflects rays away from the skin versus chemical sunscreens which sit on the skin and absorb the UV radiation like a sponge. 

    Mineral sunscreens can be a little more difficult to apply. Traditionally mineral sunscreens were thick stripes, you might remember bright white or coloured strips on noses at the beach or on the ski slopes. If that’s not the look you are going for then you’ll want to choose a more modern type. Nowadays mineral sunscreens can be easily applied and rub in well without leaving any residue or streaks. 

    If you want to avoid the absorption of chemicals in sunscreen then a mineral screen may be better. Many people with sensitive skin or conditions such as eczema may find a mineral sunscreen more suitable, as they are not absorbed into the skin there is less chance of causing irritation. 

    Pigmentation on the face can be frustrating, especially if it becomes darker quickly in the sun. Mineral sunscreens can be more effective in preventing further pigment change. 

    Most good skincare brands now offer a mineral option. The ones below have been tried and tested by the Coyne Medical team. 

    Avène Very High Protection Mineral Fluid SPF50+ Sun Cream for Intolerant Skin

    Avène also do some great tinted options

    Bioderma Photoderm MINERAL Fluide SPF50+

    Heliocare 360 Mineral Tolerance Fluid SPF 50

    It’s well worth finding a sunscreen that suits your skin, especially for the face area. As definitely the best sunscreen is the one you are happy to apply regularly!

    British Society for Genetic Medicine  ·  European Atherosclerosis Society  · 
    Independent Doctors Federation

    As seen in BBC, The Guardian, Women’s Health, The Times and Tatler

    For educational purposes. This article is written by a practising GP and is intended to inform, not replace a consultation with your own doctor. It does not constitute medical advice. A note on clinical guidelines: Coyne Medical is an independent private clinic. Our approach is guided by the best available evidence, tailored to each individual. This may go beyond standard NHS or NICE guidance, which is designed for population-level care and weighted by resource constraints.

  • Everything you need to know about genetic testing for Alzheimer’s disease

    Everything you need to know about genetic testing for Alzheimer’s disease

    TV presenter and journalist, Fiona Phillips, recently shared her Alzheimer’s disease diagnosis at the age of 61. Fiona has been an ambassador for Alzheimer’s Society and has undergone genetic testing for Alzheimer’s due to her family’s history with the disease (both her mother & father had Alzheimer’s). 

    Since Fiona shared her diagnosis, many of our patients have been in touch with questions, particularly those with a family history of Alzheimer’s disease and dementia. In this latest article we want to share everything you need to know about genetic testing for Alzheimer’s disease:

    What is Alzheimer’s disease?

    Alzheimer’s disease is a physical illness which damages a person’s brain, eventually leading to dementia. Alzheimer’s disease is the most common cause of dementia, which describes a set of symptoms that over time can affect memory, problem-solving, language and behaviour. Alzheimer’s disease is the most common type of dementia.

    In Alzheimer’s disease ‘plaques’ composed of proteins (called amyloid and tau) build-up in the brain, making it harder for the brain to function properly. Often there are other ‘vascular’ factors that cause harm to the brain. These could be high cholesterol lipoproteins as well as high blood pressure.

    What are the causes of Alzheimer’s disease?

    Alzheimer’s disease is the most common cause of ‘dementia’. The many causes of dementia all cause difficulties in memory, problem-solving, and thinking. Symptoms can be subtle at the start. It may take years before they are severe enough to cause a problem in your day-to-day life.

    I have heard of a blood test to check for the risk of Alzheimer’s disease. What is the test?

    Last year Chris Hemsworth revealed he had a high risk of Alzheimer’s disease after a genetic APOE test.

    Testing for the gene changes that have been linked to early-onset Alzheimer’s might be useful for someone with a family history of the disease or for someone showing symptoms of early-onset disease. At Coyne Medical we offer APOE gene testing, in the form of a blood test, as an add-on to our health and genetic screening services. Please do get in touch if you would like to discuss APOE gene testing in more detail.

    What is the APOE gene?  

    APOE is a gene located on chromosome 19. There are three variations of APOE you can inherit, called ‘alleles’, epsilon (ε) 2, 3 and 4. You inherit any two combinations of ε2, ε3 or ε4, as you get one copy from each parent. For example your APOE genes could be ε2/ε2, or ε2/ε4 . ε4 is the variant which carries an increased risk. If you inherit two copies of ε4 your risk of Alzheimer’s dementia is 8 to 12 times the risk of someone with two copies of ε2.

    APOE genes alone won’t guarantee someone gets Alzheimer’s disease. Lots of other factors will influence this. Blood pressure, diet, cholesterol and physical activity levels all have an impact.

    About 1% of cases develop dementia due to an inherited genetic mutation in a single gene. One example is the amyloid precursor protein gene (APP). There may be a family history of dementia starting at a very early age, from 30 onwards. In these cases, it is important to talk to your doctor and consider your options for testing.

    British Society for Genetic Medicine  ·  European Atherosclerosis Society  · 
    Independent Doctors Federation

    As seen in BBC, The Guardian, Women’s Health, The Times and Tatler

    For educational purposes. This article is written by a practising GP and is intended to inform, not replace a consultation with your own doctor. It does not constitute medical advice. A note on clinical guidelines: Coyne Medical is an independent private clinic. Our approach is guided by the best available evidence, tailored to each individual. This may go beyond standard NHS or NICE guidance, which is designed for population-level care and weighted by resource constraints.

  • VO2max Testing

    VO2max Testing

    At Coyne Medical, we are incredibly passionate about the use of exercise as medicine. A huge amount of medical evidence now shows that low levels of fitness are associated with an increased risk of dying from any cause, including heart and vascular disease and cancer rates. In comparison to smoking, having high blood pressure, high cholesterol, or type 2 diabetes mellitus, fitness is a stronger predictor of death. The fitter you are, the lower your chance of dying. The addition of fitness metrics to the standard medical risk variables enables medical professionals to more precisely categorise your disease risk. Being unfit is a massive risk factor for disease. 

    Higher fitness levels are not only associated with a lower risk of death. High fitness is also associated with a lower risk of chronic diseases. The least-fit and next-least-fit groups of people have the most to gain from increased fitness. With increased fitness, these groups have seen a massive reduction in adverse health outcomes. Indeed, bringing VO2 max from the “low” range to merely “below average” reduces mortality by 50%! So there is no need to come anywhere close to the world record of the highest VO2 max of 96.7 ml/kg/min. This highest-ever VO2 max was achieved by Norwegian cyclist Oskar Svendsen. Their cardiovascular risk also declines substantially with increased fitness. Ideally, all adults should have their fitness measured on a regular basis, just like any other preventative check, such as checking blood pressure. The most accurate way to measure your fitness is through a VO2 max test.

    Higher fitness levels are not only associated with a lower risk of death. High fitness is also associated with a lower risk of chronic diseases. The least-fit and next-least-fit groups of people have the most to gain from increased fitness. With increased fitness, these groups have seen a massive reduction in adverse health outcomes. Indeed, bringing VO2 max from the “low” range to merely “below average” reduces mortality by 50%! So there is no need to come anywhere close to the world record of the highest VO2 max of 96.7 ml/kg/min. This highest-ever VO2 max was achieved by Norwegian cyclist Oskar Svendsen. Cardiovascular risk also declines substantially with increased fitness. Ideally, all adults should have their fitness measured on a regular basis, just like any other preventative check, such as checking blood pressure. The most accurate way to measure your fitness is through a VO2 max test. 

    VO2 Max Testing

    VO2 max testing is a form of cardiopulmonary exercise testing (CPET). It is a method used to assess the performance of the heart and lungs at rest and during exercise. VO2 max testing is totally non-invasive. During the test, information about the heart and lungs is collected to understand if the body’s response to exercise is normal. 

    VO2 max, or maximal oxygen consumption, refers to the maximum amount of oxygen that an individual can utilise during intense or maximal exercise. This measurement is generally considered the best indicator of cardiovascular fitness and aerobic endurance. The more oxygen a person can use during high-level exercise, the more energy a person can produce. This test is the gold standard for determining fitness because the muscles need oxygen for prolonged aerobic exercise and the heart must pump adequate amounts of blood through the circulation to meet the demands of the exercise. There is a strong association between VO2 max and longevity. Thus, knowing VO2 max gives us a powerful metric that we know is associated with longevity and that we can objectively improve. That’s right, we can improve our VO2 max. 

    The benefits of VO2 max testing

    Aside from providing the impetus to get fitter in order to live longer, there are several reasons why VO2 max testing is so important:

    • Your current fitness can be accurately measured. This allows doctors to accurately classify your risk of a whole host of diseases. 
    • It allows the capability to create a really efficient, bespoke training programme tailored to you. 
    • It allows the evaluation of the effectiveness of a training programme 
    • It can establish what is optimal running speed or cycling wattage to maximally improve endurance fitness and optimally burn fat
    • It can assist in distinguishing causes of low fitness from cardiac or pulmonary causes
    • From a doctor’s perspective, it can be used to provide helpful prognostic information in those suffering from chronic diseases

    The data obtained from VO2 max testing enables the most precise and standardised quantification of fitness. The primary advantage is the direct measurement of fitness. This is  as opposed to estimating peak or maximal VO2. Establishing exercise intensities (training zones) based on VO2 max testing allows athletes to minimise the risk of injury and fatigue while also enhancing adaptations and responses to the training plan. 

    Older athletes, or those with underlying medical conditions, can also benefit from VO2 max testing. This is because it can provide risk stratification for disease. It also allows safe clearance to participate in sports events. VO2 max can also be used to set training zones and determine exercise limitations for older athletes.

    How VO2 Max is measured

    By putting on a face mask, the volume and gas concentrations of inspired and expired air can be directly measured. This measure is often used in research and is considered the most accurate. The test involves either exercising on a treadmill or a stationary bike. The intensity increases every few minutes until exhaustion. Thus, it is designed to achieve maximal effort. 

    What You Can Learn From VO2 Max Testing

    VO2max testing provided several different metrics that are incredibly useful. 

    • VO2Max
    • This is the maximum amount of oxygen that an individual can utilise during intense or maximal exercise. 
    • As mentioned earlier, there is a strong association between VO2 max and longevity. 
        • It defines the exercise limits of the heart and lungs in healthy people.
        • It decreases with age, 8%-10% per decade in trained individuals who continue to train vigorously. 
        • Men have a VO2 max that is 10%-20% higher than women.
    • Ventilatory Threshold (also known as lactate threshold/ VT1)
        • Anaerobic (without oxygen) metabolism occurs when muscle energy demands exceed oxygen delivery to the muscles.
        • As anaerobic metabolism begins, the breathing rate and breathing effort increase to aid in CO2 removal from the body.
        • At this point, blood lactate levels start to rise, VO2 levels peak, and CO2 production accelerates. Rising lactate levels inhibit performance. So our muscle’s ability to utilise and clear lactate is very important. Training at low intensity helps us clear lactate efficiently. 
        • The measurement sets the upper limit of low-intensity training. 
      • The peak respiratory exchange ratio
        • This is the objective measure of the maximal effort of the participant 
        • It has a huge advantage over estimated maximal heart rate (HRmax), which is often derived from the commonly used equation 220-age
        • When estimated, maximal HR has a large population error of up to 12 bpm and thus is not an ideal indicator of exercise effort
        • Fitness levels have also been shown to influence the decline in maximal HR with age making HRmax even more unreliable. 
    • 2nd Ventilatory threshold (Anaerobic Threshold)
      • At this point. lactate has quickly accumulated in the blood, necessitating heavy breathing to expel CO2.
      • This represents the transition point between moderate and high-intensity exercise.
      • Thus, it sets the limits of high-intensity training

    Implications for Exercise

    Knowing the right intensity to exercise at enables you to maximally improve your fitness performance. Polarised training has been shown to lead to the greatest improvements in endurance performance. This type of training consists of mainly low-intensity, high-volume training (75%).  There is a moderate amount of high-intensity or sprint interval training (20%), and a small amount of training at threshold intensity (5%). Establishing your VT1 and VT2 will help you get the most out of your training. What you can measure, you can manage.  VO2 max is the most accurate way to measure your fitness, and maintaining a high VO2 enhances longevity.

    British Association of Sports and Exercise Medicine  ·  European Atherosclerosis Society  · 
    Independent Doctors Federation

    As seen in The Independent, The Daily Mail and Tatler

    For educational purposes. This article is written by a practising GP and is intended to inform, not replace a consultation with your own doctor. It does not constitute medical advice. A note on clinical guidelines: Coyne Medical is an independent private clinic. Our approach is guided by the best available evidence, tailored to each individual. This may go beyond standard NHS or NICE guidance, which is designed for population-level care and weighted by resource constraints.