Multi Cancer Early Detection Blood Test
Why Choose Trucheck™ Intelli?
Detects 70+ cancers
Simple blood test
Quick results in 2 weeks
Early Detection
Your Screening Journey
Step 1: Consultation
Discuss your health with a doctor and have your blood sample taken.
Fee: £1250 including pre-test and post-test consultation with the doctor, sample collection and laboratory analysis.
Step 2: Lab Analysis
Your sample is sent to a specialist lab, with results ready in 2 weeks.
Step 3: Results Review
Review results with your doctor, who will guide you on any next steps.
The Multi Cancer Early Detection Blood Test can be added to any of our health screening packages or taken as a standalone test. For a comprehensive review of your health, consider our Ultimate Health Screening package, which combines advanced tests with personalised care to help you stay ahead of potential risks.
How does the blood test find cancer?
Coyne Medical offers the Trucheck™ Intelli multi cancer blood test in London, a revolutionary way to detect over 70 cancers early.
When cancer is present in someone, it sheds tiny cells and tumour fragments into the bloodstream, called circulating tumour cells (CTCs).
These cells are the main reason cancer eventually spreads in the body, especially if they move in clusters (a group).
The Trucheck™ Intelli test can detect them in your blood sample and indicate the likely organ of origin.
Your doctor can then carry out targeted follow-up tests.
Our Fulham-based clinic provides this test as part of comprehensive health screenings or as a standalone service for proactive health management.
Frequently Asked Questions
It’s a simple, non-invasive blood test that screens for over 70 types of cancer. It can detect cancer early, even in hard-to-screen areas, and identify the likely organ of origin for precise follow-up.
This test is ideal for adults at higher risk of cancer due to age, family history, or lifestyle factors. It’s also valuable for those seeking peace of mind.
- Aged 40 years of age or older
- Aged 35 to 39 years of age only if one of the following apply:
- a family history of cancer
- known to have an inherited cancer gene mutation e.g. BRCA1
- obesity with a BMI over 30
- type 2 diabetes
- history of infectious disease linked to cancer e.g. hepatitis B or C
- history of exposure to cancer causing chemical e.g. through work
The test has been validated in clinical trials, showing high sensitivity and specificity for cancer detection, especially for aggressive cancers.
- Trucheck™ Intelli is a blood test that can detect more than 70 types of early-stage cancer in people without any symptoms.
- The sensitivity is 88.2% – meaning that for every 100 patients tested who have cancer, it will correctly identify 88 of those patients, resulting in a 12% false negative rate.
- The specificity is 96% – meaning that for every 100 people tested, that do not have cancer, Trucheck ™ Intelli will correctly identify 96 of these individuals, resulting in a 4% false positive rate.
- False positives occur in all screening tests, the 4% level in Trucheck tests compares very favourably with other cancer screening such as PSA testing (75%), FIT testing (25%) and mammograms (7-12% at first mammogram) which all have much higher false positive rates.
If a cancer signal is detected, your results will include the likely organ of origin. This will help to decide on what tests to do next, remember that a positive result means a high risk of cancer but it is not confirmed. Your doctor will guide you on the next steps, which may include further tests or specialist referrals.
Results are typically available within two weeks. Your doctor will contact you as soon as they are ready.
No, this test is a complement to routine screenings like mammograms or colonoscopies, not a replacement. It helps detect cancers that lack routine screening methods.
The Trucheck™ Intelli can detect over 70 types of cancer. Including the most common cancers; breast, bowel, prostate, ovarian, and lung cancers (see full list below).
Trucheck™ cannot detect blood or lymphatic system cancers because CTCs are associated with solid organ malignancies.
- Adenocarcinoma ( Salivary Duct, Thyroid, Breast, lung, Oesophagus, Stomach, Duodenum,
Jejunum, Ileum, Colon, Rectum, Pancreas, Gallbladder, Bile Duct, Liver, Ovary, Prostate, Uterus); - Squamous Cell Carcinoma (SCC; Buccal Mucosa, Hard Palate, Larynx, Lip, Oral Cavity, Paranasal Sinus, Pharynx, Pyriform Fossa, Retromolar Trigone, Soft palate, Tongue, Tonsil, Oesophagus, Lung, Penis, Cervix, Vulva, Vagina, Anorectal, Skin);
- Adenosquamous Carcinoma (Oesophagus, Lung);
- Neuroendocrine (Lung, Esophagus, Duodenum, Jejunum, lleum, Thymus, Adrenal, Pancreas, Prostate, Colon, Rectum);
- Renal Cell Carcinoma (Kidney);
- Transitional Cell Carcinoma (Bladder, Renal Pelvis, Ureter);
- Gastrointestinal Stromal tumors (Stomach, Duodenum, lleum, Jejunum, Colon, Rectum);
- Melanomas (Cutaneous, Mucosal);
- Mesothelioma (Plural, Peritoneal);
- Sarcomas (Carcinosarcoma, Chondrosarcoma, Leiomyosarcoma, Osteosarcoma, Liposarcoma);
- Small Cell Lung Cancer (Lung);
- Glioma.
No. The test is designed for people without symptoms. If you have symptoms, you should seek urgent medical advice.
In the future, the tests may be used to help guide which patients with symptoms need further checks such as a biopsy but this is still at a research stage.
In studies, the test is positive in both early and late-stage cancers. This is good because many current tests only detect cancers when they are at an advanced or late stage. Early diagnosis is likely to make treatment more successful.
No. It is only suitable for people who have not had cancer.
There are other similar tests available to monitor patients after cancer treatment. We would recommend you speak with your treating doctor or surgeon to see if there is a test suitable for you.
It can be a useful addition to your yearly health screening or medical check-up. You should discuss this with your Doctor how often or when is the right time for you to test.
If you have more questions about the test itself then the laboratory has lots of detailed scientific information available here.
Take control of your health today. Book your cancer screening with Coyne Medical
Still Have Questions? We're Here to Help.
Drop us an email to reception@coynemedical.com or give us a call on 02077313077.
Learn More About Cancer Screening With Us
Genetic Screening London – Coyne Medical
Genetic Screening
Take Control: Use Genetic Screening to Protect Your Future
Our Co-Founder, Dr. Lucy, was researching genetic screening for her patients when she discovered her own gene mutation. With a breast cancer risk of over 60%, she chose a risk-reducing mastectomy, lowering her risk to less than 5%. Now, she’s passionate about giving every patient the same opportunity to take control of their health and prevent cancer.
Why Genetic Screening Matters
Get vital insights into inherited health risks and take proactive steps to protect your future.
Early Detection
Identify health risks before they become problems.
Most people only discover their genetic risks after they or a loved one has been diagnosed with cancer.
Targeted Prevention
Focus on actionable genes where steps like screenings, lifestyle changes, or surgeries can make a difference.
Personalised Treatment
Understand how your body responds to medications to optimise your health.
Family Impact
Provide valuable information to guide health decisions for loved ones too.
Why Choose Coyne Medical
Expert Guidance Every Step of the Way
Our experienced GPs are with you every step of the way. From understanding your genetic results to creating a personalised plan for care and prevention.
Actionable Results, Not Just Data
We focus only on genes where steps can be taken to reduce risk or improve treatment, ensuring every result is meaningful and actionable.
Advanced Technology
Our genetic tests use state-of-the-art next-generation sequencing (NGS) technology for the highest accuracy and reliability.
Long-Term Support Beyond Screening
We’re not just a one-stop testing clinic. At Coyne Medical, we’re committed to your long-term health. Whether it’s follow-up care, regular monitoring, or managing lifestyle changes, we’ll be with you every step of the way.
Our team ensures your plan includes access to the latest advancements in screening and London’s leading consultants, so you receive the highest standard of care at every stage of your health journey.
A Personal Commitment to Care
Our co-founder, Dr. Lucy, understands the importance of genetic screening firsthand and is passionate about bringing the same life-changing insights to our patients.
Your Genetic Screening Journey: What To Expect
Step 1: Consultation with Your Doctor
Discuss your health and family history with our doctors. We’ll explain the test and answer your questions.
Step 2: Sample Collection
Choose a saliva sample for our 31-gene test or a blood sample for our 51-gene and pharmacogenomics test.
We’ll handle all logistics to ensure precise analysis.
Step 3: Results Review
Review your results with your doctor. Together, you’ll create a personalised prevention or treatment plan.
Step 4: Ongoing Care and Long-Term Support
Get long-term support, including regular follow-ups, additional screenings, and guidance for managing health risks.
Choose The Right Genetic Screening For You
Genetic Screening is included in our Ultimate Health Screening package for a truly comprehensive approach to your health. You can also add it to any of our other health screening packages or choose it as a standalone test, tailored to your needs.
Option 1: 31-Gene Cancer Screen
- What It Covers:
Designed to identify inherited risks for common cancers by analyzing 31 key genes. - Sample Type: Saliva 🧪
- Fee: £900, including pre-test and post-test consultation with the GP, sample collection, lab analysis, and follow-up plan.
- Who It’s For:
Individuals with a family history of cancer or those seeking targeted cancer risk insights.
Option 2: 51-Gene Cancer + Pharmacogenomic Screen
- What It Covers: Comprehensive testing for 51 cancer-related genes 🧬 and 22 pharmacogenomic genes 💊 to assess cancer risks and how your body responds to medications.
- Sample Type: Blood
- Fee: £1300, including pre-test and post-test consultation with the GP, sample collection, lab analysis, and follow-up plan.
- Who It’s For: Individuals seeking both cancer prevention insights and tailored medication guidance.
The Importance of Genetic Screening
Over 95% of people in the UK with high-risk cancer gene mutations—such as BRCA1, BRCA2, or Lynch Syndrome—are undiagnosed. Early detection offers a chance to act before a problem arises. At Coyne Medical, our mission is to ensure more families can stay ahead of these risks by making genetic screening accessible and actionable.
Understanding Pharmacogenomics
Your DNA, Your Medicine: The Power of Pharmacogenomics
Pharmacogenomics analyzes how your DNA influences your response to medications, helping your doctor choose the right drug at the right dose for you.
- Analyze 22 genes that predict your response to common medications.
- Covers anti-depressants, painkillers, cholesterol-lowering drugs, cardiac medications, and more.
- Helps reduce the risk of side effects and ensures the medication you take is as effective as possible.
Did you know? 20% of new prescriptions in the UK could be changed if doctors knew a patient’s pharmacogenomics results in advance.
- Your results don’t just guide your current prescriptions—they provide valuable insights for the rest of your life.
Optimise Your Medications with Pharmacogenomic Testing
Frequently Asked Questions
Genes are small sections of DNA that provide the instructions that give us our individual characteristics. Our genes determine the colour of our eyes and hair, our height and other physical characteristics. Genetic testing looks at variations in these genes that determine whether you might be predisposed to certain diseases. Genetic testing can also tell us how your body might respond to drugs.
Our genetic screening tests over 70 gene variants that can predispose to cancer and tell us about how your body reacts to drugs. Importantly, all of these gene variants can be acted upon to help prevent or reduce the risk of the condition. Or for the pharmacogenetic genes can help guide drug treatment either now or in the future.
Providing a DNA sample is very simple.
The sample depends on the test chosen.
51 cancer gene screening PLUS pharmacogenomics uses a normal blood sample.
31 cancer gene screening uses a saliva test. Taken in clinic you simply spit into the tube.
We work with two specialist genetic testing laboratories who both registered and highly respected for specialist genetic testing. The laboratories uses the highest standard of genetic testing called NGS (next generation sequencing). This is the most accurate method. Some online DNA testing and family history companies use other methods such ‘genotyping’; this leads to more common false positive and negative results. They can be fun and quick to use but are not meant to guide medical decisions or healthcare.
We expect your laboratory report to be available within 6 weeks of your appointment. This timeframe ensures the highest accuracy and reliability from our trusted labs. We will contact you when it is available to arrange a follow-up consultation.
The Association of British insurers and the British Medical Association have agreed on a set of questions that insurers can ask your GP when you apply for life insurance. Your GP will be asked about any medical condition that you have suffered in the past or are currently experiencing that may reduce your life expectancy. They are also allowed to ask you and your GP about your family history. They are not allowed to ask or request the results of any predictive genetic testing.
Currently, the only exception in the UK to this is if you are applying for insurance with the only exception being if you are applying for life insurance over £500,000 and you have had a predictive genetic test for Huntington’s Disease. Only in this circumstance do you need to tell the insurance company the result of the test, if they ask.
If you have a strong family history of breast cancer for example and you test negative for genes related to this it may be in your interest to disclose this and you may choose to do this. You can read more about the code of the Association of British Insurers here.
There are two possible outcomes from our cancer gene testing:
Negative and positive.
If the result is negative it means that the test did not pick up any genes that increase the risk of disease. It doesn’t mean that you will never develop one of the conditions tested for, as there are many other factors aside from genes that can contribute to developing a disease. As we learn more about genetics and disease, it may be that your test results in the future will be updated to reflect new medical information. If this is the case, we will inform you immediately.
A positive result means you have discovered a gene variant that increases the risk of you developing a certain cancer. You will then be able to work with your doctor to determine what the next steps are for you. This may include options to prevent disease or increased surveillance to detect the disease at an earlier, more treatable stage.
Your pharmacogenetic testing will likely show several different variants, in your report there will be detailed recommendations on medications. This might include advice to reduce doses or consider alternative medicines for common drugs such as cholesterol medicines, pain killers and antidepressants.
We ensure the highest level of security for your personal information. Full details of our privacy policy are available here. We use our patient portal to securely share copies of your results by email. We can use an alternative method of communication if you wish – just let us know.
The genetic testing laboratory receive your personal information and abide by the extremely strict rules on privacy of sensitive data. You must consent to their receiving and sharing your personal information and data. You may choose to opt-out of anonymised research studies.
We only use medical-grade genetic testing. We use a leading specialist laboratories, who are fully accredited to ISO 15189 and 17025.
Our genetic testing uses both full-gene sequencing and deletion/duplication analysis using next-generation sequencing technology (NGS). This is the most accurate method. Some online DNA testing and family history companies use other methods such ‘genotyping’; this leads to more common false positive and negative results. They can be fun and quick to use but are not meant to guide medical decisions or healthcare.
51 cancer gene screening PLUS pharmacogenomics – £1300
31 cancer gene screening – £900
Fees include pre test consultation with the doctor, review of medical and family history, and sample taking. Laboratory analysis. Full report and advice on further screening or risk reduction for any positive cancer risk genes. Detailed report on your pharmacogenetics including advice on medications, dosages, side effects and alternatives.
Follow-up consultation with the doctor at our clinic to discuss your results. Including advice on further referrals and any other health screening indications.
Yes we believe genetic screening is a really powerful addition to our health screening. Check out our packages here.
Can I see a list of which genes will be tested?
Tumour genes include those related to:
Breast cancer
Ovarian cancer
Uterine cancer
Colorectal cancer
Cutaneous melanoma
Gastric cancer
Pancreatic cancer
Prostate cancer
Renal cell cancer
Thyroid cancer
Full List of Genes Tested
APC | CDH1 | MLH1 | POLD1 | SDHB | TSC2 |
ATM | CDKN2A | MSH2 | POLE | SDHC | VHL |
AXIN2 | CHEK2 | MSH6 | PTCH1 | SDHD | WT1 |
BAP1 | DICER1 | MUTYH | PTEN | SMAD4 | |
BARD1 | EPCAM | NBN | RAD51C | SMARCA4 | |
BMPR1A | FH | NF1 | RAD51D | SMARCB1 | |
BRCA1 | FLCN | NF2 | RB1 | STK11 | |
BRCA2 | KIT | PALB2 | RET | TMEM127 | |
BRIP1 | MEN1 | PDGFRA | SDHA | TP53 | |
CDC73 | MET | PMS2 | SDHAF2 | TSC1 |
Tumour genes include those related to:
Breast cancer
Ovarian cancer
Uterine cancer
Colorectal cancer
Cutaneous melanoma
Gastric cancer
Pancreatic cancer
Prostate cancer
Renal cell cancer
Thyroid cancer
Full List of Genes Tested
APC | CDH1 | MLH1 | POLD1 | SDHB | TSC2 |
ATM | CDKN2A | MSH2 | POLE | SDHC | VHL |
AXIN2 | CHEK2 | MSH6 | PTCH1 | SDHD | WT1 |
BAP1 | DICER1 | MUTYH | PTEN | SMAD4 | |
BARD1 | EPCAM | NBN | RAD51C | SMARCA4 | |
BMPR1A | FH | NF1 | RAD51D | SMARCB1 | |
BRCA1 | FLCN | NF2 | RB1 | STK11 | |
BRCA2 | KIT | PALB2 | RET | TMEM127 | |
BRIP1 | MEN1 | PDGFRA | SDHA | TP53 | |
CDC73 | MET | PMS2 | SDHAF2 | TSC1 |
Tumour genes include those related to:
Breast cancer
Ovarian cancer
Uterine cancer
Colorectal cancer
Cutaneous melanoma
Gastric cancer
Pancreatic cancer
Prostate cancer
Renal cell cancer
Thyroid cancer
Full List of Genes Tested
APC, ATM, BAP1, BARD1, BMPR1A, BRCA1, BRCA2, BRIP1, CDH1, CDK4, CDKN2A, CHEK2, EPCAM, HOXB13, MLH1, MSH2, MSH6, MUTYH, NF1, NTHL1, PALB2, PMS2, POLD1, POLE, PTEN, RAD51C, RAD51D, SMAD4, STK11, TP53, VHL
Tumour genes include those related to:
Breast cancer
Ovarian cancer
Uterine cancer
Colorectal cancer
Cutaneous melanoma
Gastric cancer
Pancreatic cancer
Prostate cancer
Renal cell cancer
Thyroid cancer
Full List of Genes Tested
APC | CDH1 | MLH1 | POLD1 | SDHB | TSC2 |
ATM | CDKN2A | MSH2 | POLE | SDHC | VHL |
AXIN2 | CHEK2 | MSH6 | PTCH1 | SDHD | WT1 |
BAP1 | DICER1 | MUTYH | PTEN | SMAD4 | |
BARD1 | EPCAM | NBN | RAD51C | SMARCA4 | |
BMPR1A | FH | NF1 | RAD51D | SMARCB1 | |
BRCA1 | FLCN | NF2 | RB1 | STK11 | |
BRCA2 | KIT | PALB2 | RET | TMEM127 | |
BRIP1 | MEN1 | PDGFRA | SDHA | TP53 | |
CDC73 | MET | PMS2 | SDHAF2 | TSC1 |
Pharmacogenetics illustrates how genetic changes can affect the influence of drugs. Genetic changes in the proteins responsible for absorption, distribution, metabolism, and excretion of drugs can have a huge impact on their effectiveness and compatibility. Some drugs have different effects on different people, e.g. antidepressants, analgesics, neuroleptics, chemotherapeutics, AIDS medication, thrombosis medication, anaesthetics, beta-blockers, and statins. Reduced or missing activity of a specific enzyme may increase the drug dosage and cause unwanted side effects. On the other hand, a medication that is activated by metabolism may not work if an enzyme is inactive. Enhanced enzyme activity can also affect the response to medication, e.g. by degrading the active ingredients.
Full List of Genes
ABCG2 | CYP2D6 | G6PD | NUDT15 | UGT1A1 |
CACNA1S | CYP3A4 | HLA-A | POR | VKORC1 |
CYP2B6 | CYP3A5 | HLA-B | RYR1 | |
CYP2C19 | CYP4F2 | IFNL3 | SLCO1B1 | |
CYP2C9 | DPYD | MT-RNR1 | TPMT |
Still Have Questions? We're Here to Help.
Drop us an email to reception@coynemedical.com or give us a call on 02077313077.