Genetic Screening
How can a test keep me healthy?
A simple saliva test can tell us if you are at high risk of many cancers, heart diseases and other long term conditions.
We all know most of the things we need to do to stay healthy like eating well and exercising. For most people that is enough but not everyone is average. What if your genes mean that actually there is more you can do to reduce your personal risk?
Breast Cancer Genetics
Over 95% of people in London with a BRCA mutation don't know.
We are on a mission to change that.
For many cases of breast cancer we can’t predict or prevent them. But in the case of people with a cancer gene mutation we can.
Anyone can inherit a breast cancer gene mutation. BRCA gene mutations are the most common, made famous by Angelina Jolie. A woman with one of these mutations can have an up to 80% chance of breast cancer. But most women only find out after a cancer diagnosis and most people with breast cancer have not even been tested.
Our Co-Founder Dr. Lucy was one of the first patients to take our genetic test, she didn’t have a “high-risk” family history but she did test positive for a gene mutation and was at high risk of breast cancer. Thankfully her scans were clear and she chose to have a risk-reducing mastectomy. Her risk of breast cancer has gone from over 60% to less than 5%.
1 in 6 adults will get a result which puts them at risk of serious illness.
We only test for conditions where you can take actions to reduce your risk. This might mean extra screenings or preventative treatment.
Choose The Right Test For You
Cancer Genes
Check 61 genes associated with inherited cancers.
Includes breast cancer, ovarian cancer, uterine cancer, colorectal cancer, melanoma, gastric cancer, pancreatic cancer, prostate cancer, kidney cancer, and thyroid cancer.
Cardiac Gene Screen
Checks 77 genes that can cause inherited heart diseases.
Includes genes that predispose to arrhythmias (abnormal heart rhythm), cardiomyopathies (heart muscle diseases), thrombophilia (blood clots), high blood pressure, and high cholesterol.
Complete Genetic Health Screen
Our most complete check.
Up to 147 genes including all the Cancer and Cardiac screen genes.
Plus some additional actionable inherited illnesses.
How Does It Work
Book
Choose your test and book online.
Test
We will talk you through the test and discuss your personal and family history.
The test is a simple saliva sample.
Results
You will get your results in about 3 to 4 weeks. We include a free follow-up consultation for everyone and you'll get your personal report. If your result shows a mutation we will talk you through what it means and guide you on your treatment.
Book Today
Have more questions? Check out our Frequently Asked Questions Below. Or drop us an email to reception@coynemedical.com
Frequently Asked Questions
Finding the right genetic test depends on what answers you and your doctor are trying to find. It also depends on your current medical conditions and family history of medical conditions. We will ask you questions about your family history which can help you decide on the right test for you. People with a personal or strong family history of breast cancer, for instance, may have a specific panel of gene tests targeted at this. You can then choose to go on to have the other tests at no additional charge. If you don’t know your full history or are not sure, don’t worry.
Genes are small sections of DNA that provide the instructions that give us our individual characteristics. Our genes determine the colour of our eyes and hair, our height and other physical characteristics. Genetic testing looks at variations in these genes that determine whether you might be predisposed to certain diseases.
Our cancer and cardiac genetic screening tests over 140 gene variants that can predispose to potential diseases. Importantly, all of these gene variants can be acted upon to help prevent or reduce the risk of the condition.
Providing a DNA sample is very simple. Saliva samples are usually all that is needed.
Your sample is then sent by your doctor to the genetic testing laboratory in the US where it undergoes advanced sequencing. The highly-trained clinical team at the laboratory then passes on the results to your doctor.
We only use medical-grade genetic testing. We use a leading American laboratory, Invitae, who are College of American Pathologists (CAP)-accredited and Clinical Laboratory Improvement Amendments (CLIA)-certified clinical diagnostic laboratory, offering panel and single-gene genetic tests as well as exome analysis. They have tested over 2,000,000 patients worldwide.
Invitae’s assay for panel and single-gene tests includes both full-gene sequencing and deletion/duplication analysis using next-generation sequencing technology (NGS). This is the most accurate method. Some online DNA testing and family history companies use other methods such ‘genotyping’; this leads to more common false positive and negative results. They can be fun and quick to use but are not meant to guide medical decisions or healthcare.
Once your sample has been taken by your doctor the results will be available in two to four weeks.
The Association of British insurers and the British Medical Association have agreed on a set of questions that insurers can ask your GP when you apply for life insurance. Your GP will be asked about any medical condition that you have suffered in the past or are currently experiencing that may reduce your life expectancy. In the application form, your GP is instructed to not include the result of any genetic testing.
There are three possible outcomes from our genetic testing:
Negative, positive, and carrier status.
If the result is negative it means that the test did not pick up any genes that increase the risk of disease. It doesn’t mean that you will never develop one of the conditions tested for, as there are many other factors aside from genes that can contribute to developing a disease. As we learn more about genetics and disease, it may be that your test results in the future will be updated to reflect new medical information. If this is the case, we will inform you immediately.
About one in six people will have a positive result in the cancer and cardiac genetic screening. This means that our lab has discovered a gene variant that increases the risk of you developing a certain medical condition. You will then be able to work with your doctor to determine what the next steps are for you. This may include options to prevent disease or increased surveillance to detect the disease at an earlier, more treatable stage.
You may also receive a result that shows that you are a carrier of a condition. This does not increase your risk of having the condition but it does mean that you may pass it on to your children. If you have children or are planning to have children then they may be at risk of having the condition if your partner also has the condition.
We ensure the highest level of security for your personal information. Full details of our privacy policy are available here. We use our patient portal to securely share copies of your results by email. We can use an alternative method of communication if you wish – just let us know. Genetic laboratory testing is provided by Invitae. They will receive your personal information and abide by UK laws of privacy. They may use de-identified or anonymised information for research or commercial activities. Full details of their privacy policy are available here. Once you complete your sample, you will receive your personal login to Invitae’s patient portal. You may set your information sharing preferences in the portal or by emailing privacy@invitae.com at any time. It is important that Invitae have your contact information so they can share with you any new updates in medical research that may impact your results.
We only use medical-grade genetic testing. We use a leading American laboratory, Invitae, who are College of American Pathologists (CAP)-accredited and Clinical Laboratory Improvement Amendments (CLIA)-certified clinical diagnostic laboratory, offering panel and single-gene genetic tests as well as exome analysis. They have tested over 2,000,000 patients worldwide.
Invitae’s assay for panel and single-gene tests includes both full-gene sequencing and deletion/duplication analysis using next-generation sequencing technology (NGS). This is the most accurate method. Some online DNA testing and family history companies use other methods such ‘genotyping’; this leads to more common false positive and negative results. They can be fun and quick to use but are not meant to guide medical decisions or healthcare.
Cancer Genetic Screening – £550
Cardiac Genetic Screening – £550
Complete Genetic Health Screening – £650
Fees include a doctor consultation to discuss the test and your questions, sample laboratory analysis, and a follow-up consultation to discuss your results.
Can I see a list of which genes will be tested?
Full List of Genes Tested
APC ATM AXIN2
BAP1 BARD1 BMPR1A
BRCA1 BRCA2 BRIP1
CDC73 CDH1 CDK4
CDKN2A CHEK2 DICER1
EPCAM FH FLCN
GREM1 HOXB13 KIT
MAX MEN1 MET
MITF MLH1 MSH2
MSH3 MSH6 MUTYH
NBN NF1 NF2
NTHL1 PALB2 PDGFRA
PMS2 POLD1 POLE
PRKAR1A PTCH1 PTEN
RAD51C RAD51D RB1
RET SDHA SDHAF2
SDHB SDHC SDHD
SMAD4 SMARCA4 SMARCB1
STK11 TMEM127 TP53
TSC1 TSC2 VHL
WT1
Full List Of Genes Tested
ACTA2 ACTC1 ACTN2
ACVRL1 APOB BAG3
BMPR2 CACNA1C CACNB2
CALM1 CALM2 CALM3
CASQ2 CAV1 CAV3
COL3A1 CRYAB CSRP3
DES DMD DSC2
DSG2 DSP EMD
ENG F2 F5
F9 FBN1 FHL1
FLNC GDF2 GLA
GPD1L HCN4 JUP
KCNE1 KCNE2 KCNH2
KCNJ2 KCNQ1 LAMP2
LDLR LDLRAP1 LMNA
MYBPC3 MYH11 MYH7
MYL2 MYL3 MYLK
NKX2-5 PCSK9 PKP2
PLN PRKAG2 PRKG1
PROC PROS1 RBM20
RYR2 SCN5A SERPINC1
SGCD SMAD3 SMAD4
TCAP TGFB2 TGFB3
TGFBR1 TGFBR2 TMEM43
TNNC1 TNNI3 TNNT2
TPM1 VCL
Full List Of Genes Tested
ACTA2 ACTC1 ACTN2
ACVRL1 APC APOB
ATM ATP7B AXIN2
BAG3 BAP1 BARD1
BMPR1A BMPR2 BRCA1
BRCA2 BRIP1 CACNA1C
CACNA1S CACNB2 CALM1
CALM2 CALM3 CASQ2
CAV1 CAV3 CDC73
CDH1 CDK4 CDKN2A
CHEK2 COL3A1 CRYAB
CSRP3 DES DICER1
DMD DSC2 DSG2
DSP EMD ENG
EPCAM F2 F5
F9 FBN1 FH
FHL1 FLCN FLNC
GDF2 GLA GPD1L
GREM1 HAMP HCN4
HFE HJV HOXB13
JUP KCNE1 KCNE2
KCNH2 KCNJ2 KCNQ1
KIT LAMP2 LDLR
LDLRAP1 LMNA MAX
MEN1 MET MITF
MLH1 MSH2 MSH3
MSH6 MUTYH MYBPC3
MYH11 MYH7 MYL2
MYL3 MYLK NBN
NF1 NF2 NKX2-5
NTHL1 OTC PALB2
PCSK9 PDGFRA PKP2
PLN PMS2 POLD1
POLE PRKAG2 PRKAR1A
PRKG1 PROC PROS1
PTCH1 PTEN RAD51C
RAD51D RB1 RBM20
RET RYR1 RYR2
SCN5A SDHA SDHAF2
SDHB SDHC SDHD
SERPINA1 SERPINC1 SGCD
SLC40A1 SMAD3 SMAD4
SMARCA4 SMARCB1 STK11
TCAP TFR2 TGFB2
TGFB3 TGFBR1 TGFBR2
TMEM127 TMEM43 TNNC1
TNNI3 TNNT2 TP53
TPM1 TSC1 TSC2
VCL VHL WT1