Genetic Screening
Take Control: Use Genetic Screening to Protect Your Future
Our Co-Founder, Dr. Lucy, was researching genetic screening for her patients when she discovered her own gene mutation. With a breast cancer risk of over 60%, she chose a risk-reducing mastectomy, lowering her risk to less than 5%. Now, she’s passionate about giving every patient the same opportunity to take control of their health and prevent cancer.
Why Genetic Screening Matters
Get vital insights into inherited health risks and take proactive steps to protect your future.
Early Detection
Identify health risks before they become problems.
Most people only discover their genetic risks after they or a loved one has been diagnosed with cancer.
Targeted Prevention
Focus on actionable genes where steps like screenings, lifestyle changes, or surgeries can make a difference.
Personalised Treatment
Understand how your body responds to medications to optimise your health.
Family Impact
Provide valuable information to guide health decisions for loved ones too.
Why Choose Coyne Medical
Expert Guidance Every Step of the Way
Our experienced GPs are with you every step of the way. From understanding your genetic results to creating a personalised plan for care and prevention.
Actionable Results, Not Just Data
We focus only on genes where steps can be taken to reduce risk or improve treatment, ensuring every result is meaningful and actionable.
Advanced Technology
Our genetic tests use state-of-the-art next-generation sequencing (NGS) technology for the highest accuracy and reliability.
Long-Term Support Beyond Screening
We’re not just a one-stop testing clinic. At Coyne Medical, we’re committed to your long-term health. Whether it’s follow-up care, regular monitoring, or managing lifestyle changes, we’ll be with you every step of the way.
Our team ensures your plan includes access to the latest advancements in screening and London’s leading consultants, so you receive the highest standard of care at every stage of your health journey.
A Personal Commitment to Care
Our co-founder, Dr. Lucy, understands the importance of genetic screening firsthand and is passionate about bringing the same life-changing insights to our patients.
Your Genetic Screening Journey: What To Expect
Step 1: Consultation with Your Doctor
Discuss your health and family history with our doctors. We’ll explain the test and answer your questions.
Step 2: Sample Collection
At your clinic appointment you can choose a saliva sample for our 31-gene test or a blood sample for our 54-gene and pharmacogenomics test.
At-Home Testing uses an easy and simple saliva sample, delivered the next day ready to use and return.
Step 3: Results Review
Review your results with your doctor. Together, you’ll create a personalised prevention or treatment plan.
Step 4: Ongoing Care and Long-Term Support
Get long-term support, including regular follow-ups, additional screenings, and guidance for managing health risks.
Choose The Right Genetic Screening For You
Genetic Screening is included in our Ultimate Health Screening package for a truly comprehensive approach to your health. You can also add it to any of our other health screening packages or choose it as a standalone test, tailored to your needs.
Option 1: 31-Gene Cancer Screen
- What It Covers:
Designed to identify inherited risks for common cancers by analyzing 31 key genes. - Sample Type: Saliva 🧪
- Fee: £900, including pre-test and post-test consultation with the GP, sample collection, lab analysis, and follow-up plan.
- Who It’s For:
Individuals with a family history of cancer or those seeking targeted cancer risk insights.
Option 2: 54-Gene Cancer + Pharmacogenomic Screen
- What It Covers: Comprehensive testing for 54 cancer-related genes 🧬 and 22 pharmacogenomic genes 💊 to assess cancer risks and how your body responds to medications.
- Sample Type: Blood
- Fee: £1300, including pre-test and post-test consultation with the GP, sample collection, lab analysis, and follow-up plan.
- Who It’s For: Individuals seeking both cancer prevention insights and tailored medication guidance.
The Importance of Genetic Screening
Over 95% of people in the UK with high-risk cancer gene mutations—such as BRCA1, BRCA2, or Lynch Syndrome—are undiagnosed. Early detection offers a chance to act before a problem arises. At Coyne Medical, our mission is to ensure more families can stay ahead of these risks by making genetic screening accessible and actionable.
Understanding Pharmacogenomics
Your DNA, Your Medicine: The Power of Pharmacogenomics
Pharmacogenomics analyzes how your DNA influences your response to medications, helping your doctor choose the right drug at the right dose for you.
- Analyze 22 genes that predict your response to common medications.
- Covers anti-depressants, painkillers, cholesterol-lowering drugs, cardiac medications, and more.
- Helps reduce the risk of side effects and ensures the medication you take is as effective as possible.
Did you know? 20% of new prescriptions in the UK could be changed if doctors knew a patient’s pharmacogenomics results in advance.
- Your results don’t just guide your current prescriptions—they provide valuable insights for the rest of your life.
Optimise Your Medications with Pharmacogenomic Testing
Frequently Asked Questions
Genes are small sections of DNA that provide the instructions that give us our individual characteristics. Our genes determine the colour of our eyes and hair, our height and other physical characteristics. Genetic testing looks at variations in these genes that determine whether you might be predisposed to certain diseases. Genetic testing can also tell us how your body might respond to drugs.
Our genetic screening tests over 70 gene variants that can predispose to cancer and tell us about how your body reacts to drugs. Importantly, all of these gene variants can be acted upon to help prevent or reduce the risk of the condition. Or for the pharmacogenetic genes can help guide drug treatment either now or in the future.
Providing a DNA sample is very simple.
The sample depends on the test chosen.
51 cancer gene screening PLUS pharmacogenomics uses a normal blood sample.
31 cancer gene screening uses a saliva test. The saliva test can be taken at home or in clinic you simply spit into the tube.
We work with two specialist genetic testing laboratories who both registered and highly respected for specialist genetic testing. The laboratories uses the highest standard of genetic testing called NGS (next generation sequencing). This is the most accurate method. Some online DNA testing and family history companies use other methods such ‘genotyping’; this leads to more common false positive and negative results. They can be fun and quick to use but are not meant to guide medical decisions or healthcare.
We expect your laboratory report to be available within 6 weeks of your appointment. This timeframe ensures the highest accuracy and reliability from our trusted labs. We will contact you when it is available to arrange a follow-up consultation.
The Association of British insurers and the British Medical Association have agreed on a set of questions that insurers can ask your GP when you apply for life insurance. Your GP will be asked about any medical condition that you have suffered in the past or are currently experiencing that may reduce your life expectancy. They are also allowed to ask you and your GP about your family history. They are not allowed to ask or request the results of any predictive genetic testing.
Currently, the only exception in the UK to this is if you are applying for insurance with the only exception being if you are applying for life insurance over £500,000 and you have had a predictive genetic test for Huntington’s Disease. Only in this circumstance do you need to tell the insurance company the result of the test, if they ask.
If you have a strong family history of breast cancer for example and you test negative for genes related to this it may be in your interest to disclose this and you may choose to do this. You can read more about the code of the Association of British Insurers here.
There are two possible outcomes from our cancer gene testing:
Negative and positive.
If the result is negative it means that the test did not pick up any genes that increase the risk of disease. It doesn’t mean that you will never develop one of the conditions tested for, as there are many other factors aside from genes that can contribute to developing a disease. As we learn more about genetics and disease, it may be that your test results in the future will be updated to reflect new medical information. If this is the case, we will inform you immediately.
A positive result means you have discovered a gene variant that increases the risk of you developing a certain cancer. You will then be able to work with your doctor to determine what the next steps are for you. This may include options to prevent disease or increased surveillance to detect the disease at an earlier, more treatable stage.
Your pharmacogenetic testing will likely show several different variants, in your report there will be detailed recommendations on medications. This might include advice to reduce doses or consider alternative medicines for common drugs such as cholesterol medicines, pain killers and antidepressants.
We ensure the highest level of security for your personal information. Full details of our privacy policy are available here. We use our patient portal to securely share copies of your results by email. We can use an alternative method of communication if you wish – just let us know.
The genetic testing laboratory receive your personal information and abide by the extremely strict rules on privacy of sensitive data. You must consent to their receiving and sharing your personal information and data. You may choose to opt-out of anonymised research studies.
We only use medical-grade genetic testing. We use a leading specialist laboratories, who are fully accredited to ISO 15189 and 17025.
Our genetic testing uses both full-gene sequencing and deletion/duplication analysis using next-generation sequencing technology (NGS). This is the most accurate method. Some online DNA testing and family history companies use other methods such ‘genotyping’; this leads to more common false positive and negative results. They can be fun and quick to use but are not meant to guide medical decisions or healthcare.
51 cancer gene screening PLUS pharmacogenomics – £1300
31 cancer gene screening – £900
Fees include pre test consultation with the doctor, review of medical and family history, and sample taking. Laboratory analysis. Full report and advice on further screening or risk reduction for any positive cancer risk genes. Detailed report on your pharmacogenetics including advice on medications, dosages, side effects and alternatives.
Follow-up consultation with the doctor at our clinic to discuss your results. Including advice on further referrals and any other health screening indications.
Yes we believe genetic screening is a really powerful addition to our health screening. Check out our packages here.
Can I see a list of which genes will be tested?
Tumour genes include those related to:
Breast cancer
Ovarian cancer
Uterine cancer
Colorectal cancer
Cutaneous melanoma
Gastric cancer
Pancreatic cancer
Prostate cancer
Renal cell cancer
Thyroid cancer
Full List of Genes Tested
| APC | CDH1 | MLH1 | POLD1 | SDHB | TSC2 |
| ATM | CDKN2A | MSH2 | POLE | SDHC | VHL |
| AXIN2 | CHEK2 | MSH6 | PTCH1 | SDHD | WT1 |
| BAP1 | DICER1 | MUTYH | PTEN | SMAD4 | |
| BARD1 | EPCAM | NBN | RAD51C | SMARCA4 | |
| BMPR1A | FH | NF1 | RAD51D | SMARCB1 | |
| BRCA1 | FLCN | NF2 | RB1 | STK11 | |
| BRCA2 | KIT | PALB2 | RET | TMEM127 | |
| BRIP1 | MEN1 | PDGFRA | SDHA | TP53 | |
| CDC73 | MET | PMS2 | SDHAF2 | TSC1 |
Tumour genes include those related to:
Breast cancer
Ovarian cancer
Uterine cancer
Colorectal cancer
Cutaneous melanoma
Gastric cancer
Pancreatic cancer
Prostate cancer
Renal cell cancer
Thyroid cancer
Full List of Genes Tested
APC, ATM, BAP1, BARD1, BMPR1A, BRCA1, BRCA2, BRIP1, CDH1, CDK4, CDKN2A, CHEK2, EPCAM, HOXB13, MLH1, MSH2, MSH6, MUTYH, NF1, NTHL1, PALB2, PMS2, POLD1, POLE, PTEN, RAD51C, RAD51D, SMAD4, STK11, TP53, VHL
Tumour genes include those related to:
Breast cancer
Ovarian cancer
Uterine cancer
Colorectal cancer
Cutaneous melanoma
Gastric cancer
Pancreatic cancer
Prostate cancer
Renal cell cancer
Thyroid cancer
Full List of Genes Tested
| APC | CDH1 | MLH1 | POLD1 | SDHB | TSC2 |
| ATM | CDKN2A | MSH2 | POLE | SDHC | VHL |
| AXIN2 | CHEK2 | MSH6 | PTCH1 | SDHD | WT1 |
| BAP1 | DICER1 | MUTYH | PTEN | SMAD4 | |
| BARD1 | EPCAM | NBN | RAD51C | SMARCA4 | |
| BMPR1A | FH | NF1 | RAD51D | SMARCB1 | |
| BRCA1 | FLCN | NF2 | RB1 | STK11 | |
| BRCA2 | KIT | PALB2 | RET | TMEM127 | |
| BRIP1 | MEN1 | PDGFRA | SDHA | TP53 | |
| CDC73 | MET | PMS2 | SDHAF2 | TSC1 |
Pharmacogenetics illustrates how genetic changes can affect the influence of drugs. Genetic changes in the proteins responsible for absorption, distribution, metabolism, and excretion of drugs can have a huge impact on their effectiveness and compatibility. Some drugs have different effects on different people, e.g. antidepressants, analgesics, neuroleptics, chemotherapeutics, AIDS medication, thrombosis medication, anaesthetics, beta-blockers, and statins. Reduced or missing activity of a specific enzyme may increase the drug dosage and cause unwanted side effects. On the other hand, a medication that is activated by metabolism may not work if an enzyme is inactive. Enhanced enzyme activity can also affect the response to medication, e.g. by degrading the active ingredients.
Full List of Genes
| ABCG2 | CYP2D6 | G6PD | NUDT15 | UGT1A1 |
| CACNA1S | CYP3A4 | HLA-A | POR | VKORC1 |
| CYP2B6 | CYP3A5 | HLA-B | RYR1 | |
| CYP2C19 | CYP4F2 | IFNL3 | SLCO1B1 | |
| CYP2C9 | DPYD | MT-RNR1 | TPMT |
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Email us at contact@coynemedical.com or call us on 02077313077.
