Introducing the Ziwig Endotest: A Revolutionary Saliva Test for Early Endometriosis Detection

Endometriosis is a painful, often life-disrupting condition affecting millions of women worldwide. Despite its prevalence, diagnosis can take years — with the average delay currently over 8 years and 10 months.

Traditionally, the only definitive way to diagnose endometriosis was through laparoscopy, a surgical procedure under general anaesthetic. But today, a groundbreaking innovation is transforming that reality.

At Coyne Medical, we are proud to offer the Ziwig Endotest — a non-invasive, saliva-based test developed in France that enables the early detection of endometriosis without the need for surgery. Validated in large-scale clinical trials, with results published in the New England Journal of Medicine in 2023, this test is helping women access faster, safer diagnosis and timely treatment.

Endometriosis occurs when tissue similar to the uterine lining grows outside the uterus (womb), often causing:

• Chronic pelvic pain

• Heavy or painful periods (dysmenorrhoea)

• Pain during intercourse (dyspareunia)

• Digestive symptoms

• Infertility

Around 1 in 10 women of reproductive age in the UK are affected, but symptoms often overlap with conditions like IBS (irritable bowel syndrome) or pelvic inflammatory disease, making diagnosis difficult.

Nearly half of women report 10 or more GP visits before receiving a diagnosis.

Standard tests such as blood tests, hormone levels, ultrasound, or MRI can often appear normal — leaving patients feeling unheard or doubting their symptoms. The current reliance on laparoscopy delays care and can impact fertility, quality of life, and mental wellbeing.

The Ziwig Endotest® offers a powerful alternative to traditional diagnostic tools:

• Saliva-based, non-invasive

• No anaesthetic, no surgery

• Minimal preparation

• Results within 3–4 weeks

In studies across France, the test achieved:

• 97% sensitivity (correctly identifies 97 out of 100 people with endometriosis)

• 93% specificity (accurately rules out endometriosis when it’s not present)

This means women can now receive a reliable diagnosis without undergoing surgery or hospital referral — enabling earlier access to care and treatment.

The test works by detecting over 100 specific microRNA molecules present in saliva — tiny regulators that influence how genes behave in the body. These biomarkers are extracted through Next Generation Sequencing (NGS) and interpreted with advanced artificial intelligence (AI).

This cutting-edge combination of molecular biology and AI allows the Endotest® to identify even early or subtle signs of endometriosis — even when imaging and blood tests are normal.

Ziwig is also exploring this technology to diagnose ovarian cancer, fibroids, and other gynaecological conditions.

Step 1: Saliva Collection
A simple, in-clinic collection of a small saliva sample at your GP consultation.

Step 2: Laboratory Analysis
The sample is sent for processing, where RNA biomarkers are analysed using NGS and AI algorithms.

Step 3: Results
You’ll receive a report within 3–4 weeks, showing whether the biomarkers linked to endometriosis are present.

Step 4: Next Steps
Our GPs will review the results with you and develop a personalised care or referral plan as needed.

Age range: Women aged 18 to 43 years
Symptoms:

• Chronic pelvic pain

• Painful or heavy periods

• Pain during sex, urination, or bowel movements

• Rectal bleeding or shoulder-tip pain during menstruation

• Difficulty conceiving

The test can be done at any time during the menstrual cycle, including while taking hormonal treatment.

• Under 18 or over 43 years of age

• Current infections (including oral or systemic)

• History of HIV or cancer

The current delay in endometriosis diagnosis causes avoidable distress, prolonged symptoms, and fertility complications.

By offering an accurate, in-clinic diagnostic test, we can:

• Shorten time to diagnosis

• Reduce reliance on surgical procedures

• Improve early access to treatment

• Support fertility planning

Is the Ziwig Endotest® accurate?
Yes — it detects 97% of confirmed endometriosis cases and is supported by peer-reviewed research.

Is it covered by insurance?
Coverage varies by provider and policy. Please check with your insurer directly.

Is it painful?
No — the test is completely non-invasive and pain-free.

How much does it cost?
The laboratory test costs £1020, plus a GP consultation (£160) at Coyne Medical.

How do I access the test?
Book an appointment with one of our experienced GPs to confirm suitability and begin testing.

If you’re experiencing symptoms such as chronic pelvic pain, painful periods, or difficulty conceiving, early diagnosis is essential.

Our expert team at Coyne Medical offers personalised support and fast access to the Ziwig Endotest®.
Book now to explore if this test is right for you.

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